Cosmetic Ingredients
10 Hydroxy 2 Decenoic Acid (10-HDA) Powder
10 Hydroxy 2 Decenoic Acid (10-HDA) Powder Factory & Supplier
10-Hydroxy-2-Decenoic acid (10-HDA), is an important unsaturated fatty acid in royal jelly, accounting for about 50% of the total fatty acids in royal jelly, with a content of 1.4% to 2.0%. It possesses various physiological activities, including antibacterial, antitumor, antioxidant, immune-enhancing, and blood sugar-regulating effects, and is commonly used in health foods and cosmetics.
Kintainutri®'s R&D team has successfully produced royal jelly acid with a purity of over 99% using specialized chemical synthesis methods. It is a white crystalline solid at room temperature, is stable, and its structure is not easily destroyed or degraded even after prolonged storage at room temperature or high temperatures.
| Product Name | 10-Hydroxy-2-Decenoic acid powder |
|---|---|
| Appearance | White to off-white powder |
| Specification | 99% 10-HDA |
| Grade | Cosmetic Grade & Food Grade |
| Solubility | Soluble in methanol, ethanol, chloroform, and diethyl ether; slightly soluble in acetone; insoluble in water |
| Storage |
Store in a tightly sealed container in a cool, dry, and well-ventilated place. Keep away from direct sunlight, heat, moisture, and
strong oxidizing agents. Avoid prolonged exposure to air to prevent oxidation and degradation.
|
How does 10 Hydroxy 2 Decenoic Acid (10-HDA) "Work" in the body?
10-hydroxy-2-decenoic acid is absorbed by the human body and metabolized in a clear and efficient manner, without burdening the body.
First, it is oxidized in the body to become sebacic acid, a physiologically active intermediate. Sebacic acid is then broken down into short-chain dicarboxylic acids, which enter the body's "energy factory"—the tricarboxylic acid cycle—and release a large amount of energy (one molecule of sebacic acid can produce 61 ATP molecules); Metabolic products can also participate in blood sugar and lipid regulation, or be converted into citric acid, oxaloacetic acid, etc., to maintain the body's metabolic balance.
Simply put, royal jelly acid can not only be efficiently utilized by the body, but also participate in multiple physiological regulation through metabolism, which is the basis for its multiple functions.
What are the Health Benefits of 10 Hydroxy 2 Decenoic Acid (10-HDA) Powder?
10 Hydroxy 2 Decenoic Acid 10-HDA Powder For Antibacterial and Anti-inflammatory
Studies have shown that 10-HDA is a potent antibacterial agent that can significantly inhibit the growth of various bacteria and fungi, including Staphylococcus aureus, Escherichia coli, and Bacillus subtilis. Furthermore, it can inhibit the adhesion of the oral pathogen Streptococcus mutans to cell surfaces by interfering with the expression of glucosyltransferases (gtfB/gtfC).
Simultaneously, it can inhibit the release of inflammatory mediators and exert anti-inflammatory effects by regulating protein expression through the MAPK and NF-κB signaling pathways. Therefore, you can use our 10 Hydroxy 2 Decenoic Acid powder to develop drug components for treating inflammatory diseases such as arthritis and digestive system disorders.
10 Hydroxy 2 Decenoic Acid 10-HDA Powder For Immunomodulatory
10 Hydroxy 2 Decenoic Acid can regulate the function of the immune system and enhance the body's resistance. It can inhibit the expression of IL-2Rα and the production of IL-2 on activated T cells, thereby inhibiting the proliferation of xenogeneic T cells, increasing the phagocytic activity of macrophages, and inhibiting the production of inflammatory factors and nitric oxide, thus maintaining the balance of the immune system and preventing infection and disease.
10 Hydroxy 2 Decenoic Acid 10-HDA Powder For Anti-tumor
Queen bee acid is a major component of royal jelly that has anti-leukemia and anti-tumor effects. It not only significantly inhibits tumor cell growth but also promotes the phagocytic function of phagocytes, enhances bone marrow proliferation, and promotes the growth of interleukin-2 and lymphocyte subsets with anti-cancer activity, while inhibiting tumor cell invasion and adhesion.
Studies have shown that 10-HDA has anti-proliferative activity against various cancer cells, including human adenocarcinoma cells, human colon adenocarcinoma cells (CaCo-2), and pancreatic cancer cells (PaCa-44), making it a reliable ingredient for developing anti-tumor therapeutics.
10 Hydroxy 2 Decenoic Acid 10-HDA Powder For Neuroprotective
Experiments on Alzheimer's disease model mice have confirmed that 10-hydroxy-2-decenoic acid can promote the proliferation and directed differentiation of neural stem cells, drive neurogenesis, protect neurons and reduce apoptosis, while maintaining the integrity of the blood-brain barrier, thereby effectively improving learning and memory abilities.
In addition, it can alleviate neuroinflammation and inhibit excessive microglia activation through the FOXO1-mediated autophagy pathway, and has a potential preventive effect on neurodegenerative diseases, providing a new idea for the application of 10 HDA powder as an adjunct intervention for neurodegenerative diseases.
10 Hydroxy 2 Decenoic Acid (10-HDA) Powder Uses
10 Hydroxy 2 Decenoic Acid 10-HDA Supplement
Currently, our high-purity (99%) synthetic 10 Hydroxy 2 Decenoic Acid (10-HDA) Powder is mainly used in high-end functional formulations, anti-aging nutritional products, and research-grade nutritional supplements. Product dosage forms include soft capsules, freeze-dried powder capsules, oral liquids, concentrated royal jelly tablets, and compound nutritional preparations. The main effects are to enhance immunity, improve physical recovery, promote skin health, and delay aging.
10 Hydroxy 2 Decenoic Acid (10-HDA) Powder Safety & Side Effects
Existing research indicates that 10-HDA has a good safety profile. In vitro experiments show that its toxicity to normal hepatocytes (CC50 = 106.4 μg/mL) is significantly lower than that to liver cancer cells (CC50 = 59.6 μg/mL).
In animal studies, low-dose (2.5–5 mg/kg) oral administration for 2 weeks showed no hepatotoxicity or nephrotoxicity, and its use in combination with chemotherapy drugs did not exacerbate side effects. Long-term administration of high-dose (12–25 mg/kg) only caused benign weight changes.
In summary, 10 hydroxy 2 decenoic acid is safe and has low side effects at effective application doses, making it suitable for use in the research and development of pharmaceuticals, health products, and other related products.
Kintainutri® 10 Hydroxy 2 Decenoic Acid (10-HDA) Powder Advantages
✅Kintainutri®, leveraging advanced chemical synthesis technology, has successfully overcome the bottlenecks of limited natural royal jelly acid sources and difficult extraction, achieving stable mass production of ultra-high purity products exceeding 99%. Compared to natural extracts, our synthetic 10 Hydroxy 2 Decenoic Acid boasts higher purity, better batch-to-batch consistency, no pesticide residues or bee-borne contamination risks, controllable quality and safety, and a stable supply unaffected by seasons or production locations.
✅In addition, 10-HDA possesses a variety of significant physiological activities, including antibacterial, antitumor, antioxidant, immune-enhancing, blood sugar-lowering, blood lipid-lowering, and neuroprotective effects. It can be widely used in high-end anti-aging nutritional products, functional foods, research-grade supplements, and pharmaceutical development.
✅Finally, our company has a complete quality control system that can effectively ensure that our products meet international market requirements in terms of HPLC content, residual solvents, heavy metals, and batch consistency. We also have multiple international certifications such as GMP, ISO9001, ISO22000, HACCP, and KOSHER.
*Kintainutri® Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO
Reference:
[1]: https://pmc.ncbi.nlm.nih.gov/articles/PMC5099463/;
[2]: https://pmc.ncbi.nlm.nih.gov/articles/PMC8617861/;
[3]: https://www.mdpi.com/1422-0067/25/11/6023#Scientific_Claims_about_Effectiveness_of_RJ_to_Human_Health_According_to_PASSCLAIM_Classification;
[5]: https://www.mdpi.com/1422-0067/25/11/6023.
[1]: https://pmc.ncbi.nlm.nih.gov/articles/PMC5099463/;
[2]: https://pmc.ncbi.nlm.nih.gov/articles/PMC8617861/;
[3]: https://www.mdpi.com/1422-0067/25/11/6023#Scientific_Claims_about_Effectiveness_of_RJ_to_Human_Health_According_to_PASSCLAIM_Classification;
[5]: https://www.mdpi.com/1422-0067/25/11/6023.
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